diff --git a/wp-admin/options-permalink.php b/wp-admin/options-permalink.php
index c1e3e001a..a7721c45f 100644
--- a/wp-admin/options-permalink.php
+++ b/wp-admin/options-permalink.php
@@ -164,7 +164,7 @@ if ( $iis7_permalinks ) {
 <?php
 $prefix = '';
 
-if ( ! got_mod_rewrite() && ! $iis7_permalinks )
+if ( ! is_multisite() && ! got_mod_rewrite() && ! $iis7_permalinks )
 	$prefix = '/index.php';
 
 $structures = array(