diff --git a/wp-includes/ms-default-filters.php b/wp-includes/ms-default-filters.php
index ae75de748..b4d39adf4 100644
--- a/wp-includes/ms-default-filters.php
+++ b/wp-includes/ms-default-filters.php
@@ -56,4 +56,9 @@ if ( ! defined('POST_BY_EMAIL') || ! POST_BY_EMAIL ) // back compat constant.
 	add_filter( 'enable_post_by_email_configuration', '__return_false' );
 if ( ! defined('EDIT_ANY_USER') || ! EDIT_ANY_USER ) // back compat constant.
 	add_filter( 'enable_edit_any_user_configuration', '__return_false' );
+
+// WP_HOME and WP_SITEURL should not have any effect in MS
+remove_filter( 'option_siteurl', '_config_wp_siteurl' );
+remove_filter( 'option_home',    '_config_wp_home'    );
+
 ?>